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Latest publications

Preprints

  • Doorley LA, La Bella AA, Jones SJ, Zhao G, Asadzadeh M, Choudhury QJ, Ahmad S, Mokaddas E, Al-Obaid I, Alfouzan W, Al-Banwan K, O’Meara TR, Santiago-Tirado FH, Flores-Mireles AL, and Rybak JM. (2025) Convergent evolution on RBA1 regulates Candidozyma auris host adaptation. bioRxiv :2025.12.04.692421; doi: 10.64898/2025.12.04.692421.
  • Marrufo AM, Molina JJ, Gager C, Andersen MJ, LaBella AA, Lucas ER, Wongso E, Urmi T, Arias-Parbul K, Webster R, Stuckey PV, Kohler KN, Donahue D, Ploplis VA, Flick MJ, Castellino FJ, Santiago-Tirado FH, and Flores-Mireles AL. (2024) The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI. bioRxiv:2024.07.16.603761. doi: 10.1101/2024.07.16.603761.

Published

  • La Bella AA, Gervais NC, Kohler KN, Akegbe H, Obernuefemann CLP, Gager C, Hubbard CMM, Marrufo AM, Jacobsen ID,  Shapiro RS, Caparon MG, Hultgren SJ, Flores-Mireles AL, and Santiago-Tirado FH. (2026) The unique Efg1 fungal virulence regulon in the catheterized bladder environment. Proc. Natl. Acad. Sci. U.S.A (PNAS), 123 (30) e2533309123. Epub Ahead of Print. https://doi.org/10.1073/pnas.2533309123.
  • La Bella AA, Akegbe H, Howell C, Santiago-Tirado FH, and Flores-Mireles AL. (2026) Liquid-Infused Silicone Catheters Reduce Fungal Burden and Inflammation in Candidozyma auris Bladder Infections. mSphere, 11(5):e0009826. doi: 10.1128/msphere.00098-26.
  • Ross RL, Arias-Parbul K, Douglass ZM, Adams KL, Santiago-Tirado FH. (2026) Use of a human immortalized microglia cell line to study recognition, phagocytosis, and intracellular survival of Cryptococcus neoformans. mSphere, 11(2):e0083825. doi: 10.1128/msphere.00838-25.
  • Stuckey PV, Marine J, Figueras M, Collins A, and Santiago-Tirado FH. (2025) The Vacuolar Protein 8 (Vac8) Homolog in Cryptococcus neoformans Impacts Stress Responses and Virulence Traits Through Conserved and Unique Roles. Journal of Fungi, 11(12):877. doi: 10.3390/jof11120877.
  • Winski CJ, Stuckey PV, Marrufo AM, Agyei G, Ross RL, Urmi T, Chapman S, and Santiago-Tirado FH. (2025) Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs. mBio, 16(7):e0132125. doi: 10.1128/mbio.01321-25.
  • La Bella AA, Santiago-Tirado FH*, and Flores-Mireles AL*. (2025) Candida auris is emerging as a prevalent urinary pathogen. PLoS Pathogens, 21(5):e1013138. doi: 10.1371/journal.ppat.1013138.  *, co-corresponding authors.
  • Cohen DG, Heidenreich TM, Schorey JW, Ross JN, Hammers DE, Vu H, Moran T, Winski CJ, Stuckey P, Ross RL, Arsenault E, Santiago-Tirado FH, and Lee S. (2024) Minimal Domain Peptides Derived from Enterocins Exhibit Potent Antifungal Activity. Frontiers in Fungal Biology, 5:1506315. doi: 10.3389/ffunb.2024.1506315.
  • Arsenault Yee E, Ross RL, and Santiago-Tirado FH. (2024) Phenotypic characterization of HAM1, a novel mating regulator of the fungal pathogen Cryptococcus neoformans. Microbiology Spectrum, 12(7):e03419-23. https://doi.org/10.1128/spectrum.03419-23.
  • Ross RL and Santiago-Tirado FH. (2024) Advanced genetic techniques in fungal pathogen research. mSphere, 12:e0064323. doi: 10.1128/msphere.00643-23.
  • Stuckey PV and Santiago-Tirado FH. (2023) Fungal mechanisms of intracellular survival: what can we learn from bacterial pathogens? Infection & Immunity, 91(9):e0043422. doi: 10.1128/iai.00434-22.
  • La Bella AA, Andersen MJ, Gervais NC, Molina JJ, Molesan A, Stuckey PV, Wensing L, Nobile CJ, Shapiro RS, Santiago-Tirado FH,* and Flores-Mireles AL.* (2023) The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection. Science Advances, 9(9):eade7689. doi: 10.1126/sciadv.ade7689. *, co-corresponding authors.
  • Santiago-Tirado FH, Hurtaux T, Geddes-McAlister J, Nguyen D, Helms V, Doering TL, and Römisch K. (2023) The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans. mBio, 14(1):e0338422. doi: 10.1128/mbio.03384-22.
  • Gervais NC, La Bella AA, Wensing LF, Sharma J, Acquaviva V, Best M, Cadena López RO, Fogal M, Uthayakumar D, Chavez A, Santiago-Tirado F, Flores-Mireles AL, Shapiro RS. (2022) Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans. G3: Genes|Genomes|Genetics, jkac301. doi: 10.1093/g3journal/jkac301.
  • Santiago-Burgos EJ, Stuckey PV, Santiago-Tirado FH. (2022) Real-time visualization of phagosomal pH manipulation by Cryptococcus neoformans in an immune signal-dependent way. Frontiers in Cellular and Infection Microbiology 12:967486. doi: 10.3389/fcimb.2022.967486.
  • Winski CJ, Qian Y, Mobashery S, Santiago-Tirado FH. (2022) An Atypical ABC Transporter Is Involved in Antifungal Resistance and Host Interactions in the Pathogenic Fungus Cryptococcus neoformans. mBio 13(4):e0153922. doi: 10.1128/mbio.01539-22.
  • Santiago-Tirado FH. (2019) mSphere of Influence: the Power of Yeast Genetics Still Going Strong! mSphere 4(5). doi: 10.1128/mSphere.00647-19.
  • Santiago-Tirado FH, Klein RS, and Doering TL. (2019) An In Vitro Brain Endothelial Model for Studies of Cryptococcal Transmigration into the Central Nervous System. Current Protocols in Microbiology 53(1):e78. doi: 10.1002/cpmc.78.

2018 - 2013

  • Santiago-Tirado FH, Onken MD, Klein RS, Cooper JA, and Doering TL. (2017) Trojan horse transit contributes to blood-brain barrier crossing of a eukaryotic pathogen. mBio 8 (1): e02183-16. doi: 10.1128/mBio.02183-16.
  • Santiago-Tirado FH and Doering TL. (2017) False friends: Phagocytes as Trojan horses in microbial brain infections. PLoS Pathogens 13(12): e1006680. doi: 10.1371/journal.ppat.1006680.
  • Gish SR, Maier EJ, Haynes BC, Santiago-Tirado FH, Srikanta DL, Ma CZ, Li LX, Williams M, Crouch EC, Khader SA, Brent MR, Doering TL. (2016) Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response. mBio 7 (2): e00313-16. doi: 10.1128/mBio.00313-16.
  • Santiago-Tirado FH and Doering TL. (2016) All about that fat: Lipid modification of proteins in Cryptococcus neoformans. Journal of Microbiology 54: 212-222. doi: 10.1007/s12275-016-5626-6.
  • Santiago-Tirado FH, Peng T, Yang M, Hang HC, and Doering TL. (2015) A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome. PLoS Pathogens 11: e1004908. doi: 10.1371/journal.ppat.1004908.
  • Kumar P, Heiss C, Santiago-Tirado FH, Black I, Azadi P, Doering TL. (2014) Pbx proteins in Cryptococcus neoformans cell wall remodeling and capsule assembly. Eukaryot Cell. 13 (5): 560-71. doi: 10.1128/EC.00290-13.
  • Srikanta D, Santiago-Tirado FH, Doering TL. (2014) Cryptococcus neoformans: historical curiosity to modern pathogen. Yeast. 31 (2): 47-60. doi: 10.1002/yea.2997.

2013 and prior

  • Liu W, Santiago-Tirado FH, Bretscher A. (2012) Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation. Mol Biol Cell 23 (3): 412-22. doi: 10.1091/mbc.E11-07-0631.
  • Santiago-Tirado FH, Bretscher A. (2011) Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network. Trends Cell Biol. 21 (9): 515-25. doi: 10.1016/j.tcb.2011.05.005.
  • Santiago-Tirado FH, Legesse-Miller A, Schott D, and Bretscher A. (2011) PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast. Developmental Cell 20: 47-59. doi: 10.1016/j.devcel.2010.11.006
  • Legesse-Miller A, Zhang S, Santiago-Tirado FH, Van Pelt CK, Bretscher A. (2006) Regulated phosphorylation of budding yeast’s essential myosin V heavy chain, Myo2p. Mol Biol Cell 17 (4): 1812-21. doi: 10.1091/mbc.e05-09-0872.

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